PLSD - Prospective Lynch Syndromes Database
Aims of PLSD
Based on the observation that removal of adenomas with colonoscopy did not reduce CRC incidence as assumed, in 2012 the European Hereditary Tumor Group (EHTG), at that time denoted the Mallorca Group, decided to compile information on follow-up of path_MMR carriers across multiple specialist centres to answer three questions:
- To what degree does colonoscopy surveillance reduce CRC incidence in path_MMR carriers?
- What is the penetrance and expressivity of pathogenic variants in each of the four Lynch syndrome-associated genes?
- What is the survival of carriers when followed-up as recommended, to facilitate early diagnosis and treatment?
Legal notes
The European Hereditary Tumour Group (EHTG) - registration number SC048407 in Scotland - is responsible for PLSD. The information contained in this website is for general information purposes only. We make no representations or warranties of any kind, expressed or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, for interpretation or use in clinical practice, or otherwise contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk. In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website. For health care, see EHTG guidelines.
Technical notes
Contributions to PLSD are compared with the InSiGHT database where this PLSD website may be reached through the tab MMR CANCER RISK. Class 4 and 5 pathogenic variants in the InSiGHT database are included for calculation of PLSD results. The InSiGHT database reports which variants are pathogenic, the PLSD reports penetrance and expressivities of the pathogenic variants. The PLSD was initially established in Oracle© based on which all previous reports were calculated, and migrated to MySQL© from which results from version 5 here are reported. The complete MySQL© database structure and code is described in PMID: 36411472. For table structure see https://www.ehtg.org/plsd.php. Some details regarding background, technical issues and statistical considerations are discussed in PMID: 32190163.
Contributing
In case you want to become a PLSD contributor, please have a look at the requirements for data submission. In case of any questions, please do not hesitate to contact us.
Acknowledgments
- Website Editors:
- Saskia HauptAlexander ZeilmannSigve NakkenEivind HovigPål Møller
- Contact
- Mev Dominguez-Valentin
- PLSD Principal Investigators:
- 2012–2022Pål Møller2022–Mev Dominguez-Valentin